Fall Special Sale Up to 60% OFF|FREE Shipping on Orders $60+|Join 100,000+ Dog Parents
Product
Product
Product
Product
Product
Product
Product
Product
Product
“The vet wanted $1,400 and I couldn't sign it. Six weeks later he looked in her mouth and asked what I'd changed.”
Vicki T., one of 100,000+ Dog Moms.

DE-01™ DENTAL POSTBIOTIC

Fresher Breath by Day 14th.
No Anesthesia and No Toothbrush!
Disrupts 98% Of The Film That Builds Plaque.

Germs live on the teeth. They coat themselves in a slick film so nothing can touch them. Chews hit that film. Brushing hits that film. Sprays and water additives hit that film. The germs under it are fine. They rebuild by morning. DE-01 goes under the film. One scoop on dinner:

3 Published Studies
Under The Gumline
Where Chews Can't Reach
Dogs Lick The Bowl
Spares Good Bacteria
9X More Bad Bacteria Gone
Step 1Pick Your Dog's WeightMultiple dogs? Go up one weight class per dog.
Step 2Stock Up & Save
  • Days 7-14, the breath starts to soften
  • Weeks 4-6, the brown starts to lift
  • Day 90, you stop checking.
Order now and ships by soon
60-Day GuaranteeFree Shipping $60+Human Grade Ingredients
★★★★★4.8 / ExcellentBased on 1,863+ Reviews

Three weeks in and Maggie's breath doesn't clear the room anymore. She's 11, hates chews, but she licks the bowl clean with this on it. Wish I'd found it years ago.” — Karen M., verified buyer

See more reviews ›

Bad breath in dogs starts with biofilm, the same slime you feel on your own teeth when you wake up. The germs that cause the smell live inside it. Chews and brushing only scrub the top. They can't get under the gumline. DE-01 can. Over 100,000 dogs are already on it.

Key Benefits:

  • Fresher breath, fast: You may smell it in the first week. The study at our exact dose measured fresher breath by day 14.*
  • Skip the $1,500 cleaning: No anesthesia, and nothing to sign.
  • Breaks up biofilm: 98% of it, in lab tests.*
  • Fewer bad bacteria: Dogs taking it saw 9X more kinds of bad bacteria drop than dogs who didn't.*
  • Leaves the good ones alone: Goes after the germs behind the smell. The healthy ones stay.*
  • Fights plaque: Less film on the teeth means less for plaque to build on.
  • Beats the dental chews: In published research, it cut bad-breath compounds more than leading dental chews did.*
  • 10 seconds a day: Scoop it on the food. That's the whole routine.
  • Dogs actually eat it: Beef bone broth, beef liver and organic pumpkin. Even picky eaters lick the bowl clean.
  • 3 studies, all published: The first ingredient ever clinically studied in dogs for this. All three studies ran in peer-reviewed journals in 2025 and 2026.
  • Vet-formulated, human-grade: No fillers, corn, soy, sugar or artificial flavors. Made in USA using US & globally sourced ingredients.

*98%: in lab tests. Day 14 and dental chew comparison: published clinical study at our 150mg dose, set against two published dental chew studies. 9X and good bacteria: published clinical study at 250mg, measured at day 7, compared with dogs not given the active. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

DE-01 Postbiotic Strain
Modulates oral microbiome bacteria. The first postbiotic clinically studied in dogs for dental health.
Hero Ingredient
Why Dogs Actually Eat It
Beef Bone Broth PowderPalatability + minerals
Beef Liver PowderReal food, real flavor
Functional Support
Organic PumpkinGut-friendly fiber
Organic KelpMineral support
Oat Flour (GF)Gentle carrier
ChlorellaGreens + detox support
Organic Parsley LeafBreath support
Zinc CitrateOral health mineral
Patent-PendingNo Artificial ColorsNo Artificial FlavorsNo FillersFDA-Registered FacilityVet-Formulated

How to Use Your DE-01 Dental Dogbiotic

  • Scoop by weight: ½ scoop under 6 lbs. 1 scoop for 6 to 25 lbs. 2 scoops for 25 to 75 lbs. 3 scoops over 75 lbs.
  • Mix it into food: Stir it into your dog's bowl at mealtime.
  • Once a day: Same meal every day makes it easy to remember.
  • Keep it in the bowl: Fresher breath often shows in week 1, visible change by weeks 4-6. Give it the full 90 days. Stop, and the film builds back.

Good to know: For dogs over 12 weeks old. Not for dogs with thyroid issues. Not proven safe for pregnant or nursing dogs. If you see any side effects, stop and call your vet.

  • 1 jar of DE-01 Dental Dogbiotic, sized for your dog (Tiny/Small, Medium or Large)
  • 1 scoop

One jar is about a 30-day supply, sized to your dog. Store it at room temperature. No fridge needed. Check the date on the jar. On a subscription, a fresh jar ships every 30 days.

The 3X Promise: Fresher Breath. Stronger Gums. Less Plaque.

60 days to try it. Or every cent back. No questions.

The proof

You’ve tried the rest. Why believe us?

Clinically provenAt the exact dose in every scoop
3 published studiesAll peer-reviewed, 2025–2026
Patent-pending IngredientsA first-of-its-kind active ingredient
9 Human-Grade ingredientsEvery milligram on the label
FDA-registered facilityMade in the USA
100,000+ dog ownersAnd counting, every month

Studied. Published. Guaranteed.

Senior dog heading to a bowl topped with DE-01

5 Reasons 100,000+ Dog Owners Switched to DE-01

Nobody goes under. Nobody wrestles. Nobody turns away.

Skip the Anesthesia and the $1,500 bill
Reason 1

Skip the Anesthesia and the $1,500 bill

The vet's estimate is only the start. Then comes the fasting the night before, the 7am drop-off, and an afternoon waiting for the call that says the dog woke up. With DE-01, the dog never leaves the kitchen.

Works Even if Dinner Gets Inhaled
Reason 2

Works Even if Dinner Gets Inhaled

A chew only works while it's being chewed, and you've watched one go down in three bites. DE-01 works through saliva, not chewing. All three published studies gave it to dogs sprinkled on their food, exactly the way you will.

No Hands in a Sore Mouth
Reason 3

No Hands in a Sore Mouth

You've tried brushing an old dog's sore mouth. The flinch, the pulling away, the yelp you feel in your own chest. With DE-01 your hands stay out of it. It rides in on dinner. No brush, no scraping, no harsh chemicals.

Human-Grade Ingredients. Science-Backed Postbiotic
Reason 4

Human-Grade Ingredients. Science-Backed Postbiotic

If the last powder got sniffed at and left in the bowl, look at what this one's made of: beef bone broth and beef liver. It goes on dinner like gravy. One scoop on the food the dog already eats. Done.

No More Turning Your Cheek
Reason 5

No More Turning Your Cheek

You know the move. The dog leans in and you turn your cheek before you've even thought about it. The breath changes first, inside two weeks.* Then one night the dog is right up in your face, and you forget to turn away.

Wolf chewing a bone in the snow

Wolves Don't Brush Their Teeth. Here's Their Secret.

Bones. Wolves and wild dogs that eat whole prey, bones and all, almost never get tartar or mouth disease. Peer-reviewed research has measured it. So why not hand your dog a bone?

Because on an old dog, the wolf's secret turns on you. A sore mouth won't chew it. A gulper swallows it in chunks. One wrong bite on a hard bone and an old tooth breaks. A broken tooth gets fixed one way: under anesthesia.

DE-01 doesn't ask old teeth to do the work. It gets into the saliva, and saliva goes where a bone can't scrape: along the gumline, where the film starts, and down between every tooth. All day. All night. That's a better secret than the wolf's.

  1. One scoop on dinner
  2. It gets into the salivaAll day. All night.
  3. It reaches what a bone can'tAlong the gumline, where the film starts, and down between every tooth

Measured, Not Promised.

98%of the film that builds plaque, broken up in lab studies. The next-best common ingredient in the same test managed 41%.*
9Xmore kinds of bad bacteria knocked back in one week than in dogs that went without it.*
+38%is how much bad-breath compounds rose in 14 days in dogs that went without it. Dogs on DE-01’s active held flat.*
Pepper, 13, licking her lips next to an empty bowl
★★★★★

“I spent so much on chews and the stuff you put in the water bowl, and nothing helped. Pepper is 13 and picky, and still eats every bit. The breath went from awful to nothing at all. I only wish I'd found this sooner.”

Darlene R., 67
Your first 90 days

What You'll Notice, and When

The dog won't tell you it's working. These moments will.

Owner and dog nose to nose on the kitchen floor
1
DAYS 1-7

Just Dinner, Every Night

One scoop on the food. The dog eats it and never knows.

You might not notice much yet. That's normal, the change starts below what you can smell.

Published study

Day 7: in a published study, the mouth's bacteria had already shifted.*

2
DAY 14

You Stop Holding Your Breath

The dog yawns right next to you, and you don't lean away.

The car smells like the car again.

Published study

Day 14: where the published study at our exact 150mg dose measured fresher breath.**

3
WEEKS 4-6

The Brown Starts to Lift

By week 5 the brown on the back teeth starts to lift.

You catch yourself holding a lip up under the kitchen light, just to be sure.

4
DAY 90

You Stop Checking

The lip-lifting stops. You forget there was ever a problem.

Nobody in the house flinches anymore.

Here's Where Everything Else Stops.

Chews and brushes clean the teeth. DE-01 goes after what lives on them.

DE-01
DE-01
Dental Chews
Dental Chews
Water Additives
Water Additives
Brushing
Brushing
Goes after the bacteriathe source, not the surface
Surface only
Varies
Clears it daily
No chewing neededworks even if dinner's gulped
Only if chewed
Dogs actually take it
Some drink less
Many refuse
Easy on a sore, old mouth
Needs good teeth
Can hurt
Gets better with daily usenothing to get right but dinner
Fresh breath by day 14**A whole new mouth by day 90***
If chewed daily
If they drink
Daily, done right
Published studies in dogspeer-reviewed, not a label claim
3 published*
Some
Some

One Scoop Is 1,000 mg.Here’s Where Every Milligram Goes.

Nine human-grade ingredients: the studied active, the food that gets it eaten, and nothing hidden in between.

DE-01™ Dental Dogbiotic

Nine Ingredients. Every One Has a Job.

Makes
1 scoop
Weighs
1,000 mg
Prep
10 seconds
The DE-01 jar and a scoop of powder on a kitchen counter

100% Human-Grade

Nothing goes in your dog's bowl that isn't fit for your own plate. The studied active included.

Ingredients per 1 scoop

The Active

A level scoop of DE-01 powder

150 mg

Canine Oral Health Postbiotic (COHP)

A postbiotic made for a dog’s mouth, and published in three peer-reviewed studies in dogs.

  • Fresher breath by day 14, at this exact dose.*
  • 98% of the film that builds plaque broken up, in lab studies.**
  • Targets bad-breath bacteria and spares the good ones.***

Why Dogs Eat It

Bone broth powder on a spoon beside a mug of broth

283 mg Beef Bone Broth Powder

The biggest ingredient in the scoop, and the reason it goes on dinner like gravy.

A small pumpkin with a spoonful of pumpkin powder

248 mg Organic Pumpkin Powder

Certified organic pumpkin for a mild, familiar taste and a little natural fiber.

Thin slices of freeze-dried beef liver

37 mg Beef Liver Powder

A small amount of real liver, the smell that gets a picky dog’s nose in the bowl.

The Supporting Cast

Dried kelp fronds

150 mg Organic Kelp (Ascophyllum nodosum)

Certified organic seaweed, a natural source of iodine and trace minerals.

A small dish of green chlorella powder

50 mg Chlorella

Freshwater green algae, rich in chlorophyll, the pigment that makes plants green.

A tiny measuring spoon holding a few grains of white powder

2 mg Zinc Citrate

A mineral used in many toothpastes and dental products, here in a small, measured amount.

A single small sprig of flat-leaf parsley

5 mg Organic Parsley Powder

A pinch of organic parsley, the old breath herb. We won’t pretend 5 mg does the heavy lifting.

The Carrier

Oat flour on a spoon beside rolled oats

75 mg Oat Flour (Gluten Free)

The carrier, and we’ll say it plainly: it’s there so the powder mixes evenly into food.

Method

  1. Mix into your dog's food at mealtime. No brushing, no fighting.
  2. Repeat every day. Fresher breath by week 2, visible change by weeks 4 to 6.

Daily Serving Size

  • Tiny under 6 lbs1/2 Scoop
  • Small 6-25 lbs1 Scoop
  • Medium 25-75 lbs2 Scoops
  • Large 75+ lbs3 Scoops

Not in the scoop: No corn · No soy · No sugar · No gluten · No hormones · No antibiotics · No artificial flavors · No preservatives

Human-grade · Non-GMO · Lab tested · Made in USA using US & globally sourced ingredients

Over 100,000 Dogs Use DE-01 Daily

DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
DE-01 customer with their dog
The DE-01 Dental Dogbiotic jar
60 DAYS

The Chews Kept Your Money. This Jar Has To Earn It.

The 3X Promise

Fresher Breath. Stronger Gums. Less Plaque.

60 days to find out.

Or every cent back. No questions.

Under 1 in 50 asked for their money back and got it. The rest kept the jar.

Start My 60 Days

Frequently asked questions

Everything you want to know before you commit.

How It Works

DE-01 contains a clinically studied postbiotic that rebalances your dog's oral microbiome — the real source of bad breath. Instead of masking odors, it targets the bacteria causing them at the gum line. Most dog parents notice a meaningful difference within the first 7 days.

Yes. The postbiotic in DE-01 disrupts the biofilms that plaque and tartar build on. It won't dissolve heavy calculus overnight, but consistent daily use typically shows visible improvement in plaque accumulation and gum health around weeks 4–6.

Dental chews work by mechanical abrasion — the chewing physically scrapes the tooth surface, but only on the outer face. They don't reach below the gum line, between teeth, or into the oral microbiome. DE-01's postbiotic works biologically, targeting the bacteria that cause plaque, tartar, and bad breath at the source — while your dog eats their regular meal.

That's exactly what it's designed for. By keeping the oral microbiome balanced daily, you're stopping the bacterial buildup that leads to plaque, tartar, and gum disease before it starts. Think of it like brushing — the benefit compounds over time. Dogs who use it consistently tend to get much cleaner vet checks.

Using DE-01

Once daily, sprinkled over your dog's regular food. That's it — 10 seconds, same time every day.

Most dog parents notice fresher breath within the first week. Visible improvement in plaque and whitening typically shows up around weeks 4–6 of daily use. The 90-day mark is where the full transformation is most dramatic — cleaner teeth, healthier gums, and a noticeably fresher mouth at the vet.

Almost universally, yes. The formula is made with grass-fed beef bone broth and liver, so most dogs eat it right up. Even picky eaters tend to have no issues with this one.

Daily, ongoing — just like brushing. The benefit comes from consistency. Once your dog's oral health improves, daily use keeps it there and prevents the bacterial buildup from returning.

60 scoops per jar. For most medium-sized dogs (25–75 lbs), that's a 30-day supply at the recommended daily dose.

Absolutely. Sprinkle the scoop over whatever your dog is eating — kibble, wet food, raw, homemade, or stirred into bone broth. The key is that your dog consumes it with their meal.

Safety & Ingredients

The active ingredient is our clinically studied postbiotic dental strain. The formula also contains grass-fed beef bone broth and liver for palatability. All ingredients are human-grade — no artificial additives, no fillers, no synthetic preservatives. The full ingredient list is printed on every jar.

No. Sodium hexametaphosphate is a synthetic chelating agent found in many commercial dental foods and treats. We don't use it. DE-01 contains no synthetic chemicals, no artificial preservatives, and no fillers — human-grade ingredients only.

Yes, though we recommend waiting until your puppy has finished teething — typically around 6–7 months. After that, the daily routine is appropriate for dogs of any age.

DE-01 is formulated specifically for dogs. We don't recommend it for cats — the dosing and formulation are dog-specific, and some ingredients may not be suitable for felines.

Made in the USA. We ship from our US fulfillment center — most orders arrive within 3–5 business days.

Measured, Not Promised. *98% and 41%: in lab studies. 9X: published clinical study, 250mg, day 7. +38%: published clinical study at our 150mg dose, day 14. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What You'll Notice, and When. *Published clinical study, 250mg, day 7. **Published clinical study at our 150mg dose, day 14. ***Weeks 4 to 6 and day 90: expected timeline based on customer experience, not a measured study endpoint. Individual results vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Here's Where Everything Else Stops. *On the active in DE-01 (Canine Oral Health Postbiotic), published 2025 to 2026 in Animals and the Journal of Veterinary Dentistry. Compared by category, not brand. Products within a category vary. **Day 14: published clinical study at our 150mg dose. ***Day 90: expected timeline based on customer experience, not a measured study endpoint. All three published studies measured through day 14. Individual results vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

One Scoop Is 1,000 mg. Here’s Where Every Milligram Goes. *Published clinical study at our 150mg dose, day 14. **In lab studies. ***Published clinical study, 250mg, day 7. Amounts per 1 g scoop. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Chews Kept Your Money. This Jar Has To Earn It. Any DE-01 order, 60 days from the day you order. Email us and get the whole order total back, shipping included. You keep the jar. 1 in 50: DE-01 customers who ordered Feb 2025 to Jul 2026, refunds and chargebacks counted.

$299$79.97