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A woman laughs on her kitchen floor while her old beagle licks her chin
A woman laughs on her kitchen floor while her old beagle licks her chin
★★★★★4.8/51,922 Reviews

Don’t Spend The Last Years Turning Your Face Away.

Fresher breath by day 14. Clinically proven at the dose in every scoop.*

  • Skip The Anesthesia.Skip the bloated vet bills.
  • Nobody Gets Held Down.The toothbrush stays in the drawer.
  • Stronger Gums. Less Plaque.Gentle enough for a senior dog's mouth.
Get My Kisses Back

60 days. Or every cent back. No questions.

★★★★★4.8 out of 5Based on 1,922 Reviews

“My little Havanese Spike has the worst teeth ever! Vet told me to do dental service would be around $1400 which we cannot afford. Spike has been on your product for about two months and his teeth are so much better!”

Mona G., verified buyer

See more reviews ›
3 Published Studies
Under The Gumline
Where Chews Can't Reach
Dogs Lick The Bowl
Spares Good Bacteria
9X More Bad Bacteria Down
Only two choices

The Breath, Or Anesthesia: 1 In 75 Sick Dogs Are Lost.*

The Dog Leans In. You Lean Away.

A grey-muzzled dachshund on a woman's lap, mouth open and teeth brown, while she turns her face away.

You flinch before you decide to. A dog owner said it: “like something died in her mouth.”

The dog isn’t “slowing down.” That’s mouth pain.

or

The Vet’s “Routine” Is Full Anesthesia.

An old grey-muzzled dog rests its head on a steel exam table while a hand signs an anesthesia consent form.

“I know two separate families who lost (not especially elderly) dogs to the surgery”

A dog owner

$829.25 to $1,456.12

For one dental visit. You learn the final number once your dog is already under.

Photo of a real vet dental estimate with the two totals, $829.25 and $1,456.12, circled in red.
Real 2024 dental estimate from an Albuquerque vet clinic, name redacted. Tax included.
  • Dental chews
  • Water additives
  • Breath sprays
  • Brushing

Each works on the surface, a few minutes a day. The film rebuilds every night.

You tried. You’re not a bad owner. The system has been bad.

Wolf chewing a bone in the snow
Why nothing worked

The Free Fix Everyone Swears By Has A Catch.

Bones. Wolves and wild dogs that eat whole prey, bones and all, almost never get tartar or mouth disease. Peer-reviewed research has measured it. So why not hand your dog a bone?

Because on an old dog, the wolf's secret turns on you. A sore mouth won't chew it. A gulper swallows it in chunks. One wrong bite on a hard bone and an old tooth breaks. A broken tooth gets fixed one way: under anesthesia.

DE-01 doesn't ask old teeth to do the work. It gets into the saliva, and saliva goes where a bone can't scrape: along the gumline, where the film starts, and down between every tooth. All day. All night. That's a better secret than the wolf's.

  1. One scoop on dinner
  2. It gets into the salivaAll day. All night.
  3. It reaches what a bone can'tAlong the gumline, where the film starts, and down between every tooth
What was measured

Measured, Not Promised.

Three peer-reviewed studies in dogs, two in the Journal of Veterinary Dentistry. One ran at 150mg, the exact dose in every scoop.

98%of the film that builds plaque, broken up in lab studies. The next-best common ingredient in the same test managed 41%.*
9Xmore kinds of bad bacteria knocked back in one week than in dogs that went without it.*
+38%is how much bad-breath compounds rose in 14 days in dogs that went without it. Dogs on DE-01’s active held flat.*
What changes, when

What You'll Notice, and When

The dog won't tell you it's working. These moments will.

Owner and dog nose to nose on the kitchen floor
1
DAYS 1-7

Just Dinner, Every Night

One scoop on the food. The dog eats it and never knows.

You might not notice much yet. That's normal, the change starts below what you can smell.

Published study

Day 7: in a published study, the mouth's bacteria had already shifted.*

2
DAY 14

You Stop Holding Your Breath

The dog yawns right next to you, and you don't lean away.

The car smells like the car again.

Published study

Day 14: where the published study at our exact 150mg dose measured fresher breath.**

3
WEEKS 4-6

The Brown Starts to Lift

By week 5 the brown on the back teeth starts to lift.

You catch yourself holding a lip up under the kitchen light, just to be sure.

4
DAY 90

You Stop Checking

The lip-lifting stops. You forget there was ever a problem.

Nobody in the house flinches anymore.

Side by side

Here's Where Everything Else Stops.

Chews and brushes clean the teeth. DE-01 goes after what lives on them.

DE-01
DE-01
Dental Chews
Dental Chews
Water Additives
Water Additives
Brushing
Brushing
Goes after the bacteriathe source, not the surface
Surface only
Varies
Clears it daily
No chewing neededworks even if dinner's gulped
Only if chewed
Dogs actually take it
Some drink less
Many refuse
Easy on a sore, old mouth
Needs good teeth
Can hurt
Gets better with daily usenothing to get right but dinner
Fresh breath by day 14**A whole new mouth by day 90***
If chewed daily
If they drink
Daily, done right
Published studies in dogspeer-reviewed, not a label claim
3 published*
Some
Some
Why owners switch

5 Reasons 100,000+ Dog Owners Switched to DE-01

Nobody goes under. Nobody wrestles. Nobody turns away.

Skip the Anesthesia and the $1,500 bill
Reason 1

Skip the Anesthesia and the $1,500 bill

The vet's estimate is only the start. Then comes the fasting the night before, the 7am drop-off, and an afternoon waiting for the call that says the dog woke up. With DE-01, the dog never leaves the kitchen.

Works Even if Dinner Gets Inhaled
Reason 2

Works Even if Dinner Gets Inhaled

A chew only works while it's being chewed, and you've watched one go down in three bites. DE-01 works through saliva, not chewing. All three published studies gave it to dogs sprinkled on their food, exactly the way you will.

No Hands in a Sore Mouth
Reason 3

No Hands in a Sore Mouth

You've tried brushing an old dog's sore mouth. The flinch, the pulling away, the yelp you feel in your own chest. With DE-01 your hands stay out of it. It rides in on dinner. No brush, no scraping, no harsh chemicals.

Human-Grade Ingredients. Science-Backed Postbiotic
Reason 4

Human-Grade Ingredients. Science-Backed Postbiotic

If the last powder got sniffed at and left in the bowl, look at what this one's made of: beef bone broth and beef liver. It goes on dinner like gravy. One scoop on the food the dog already eats. Done.

No More Turning Your Cheek
Reason 5

No More Turning Your Cheek

You know the move. The dog leans in and you turn your cheek before you've even thought about it. The breath changes first, inside two weeks.* Then one night the dog is right up in your face, and you forget to turn away.

A dog like yours

Too Old? Too Picky? Tried Every Chew?

Six owners who had the same doubts. Their words, quoted as written, trimmed only where you see …

★★★★★4.8/51,922 Reviews
Senior dog
★★★★★· Mar 8, 2026
Jill H.Verified buyer
Before starting Penny on Dogbiotics, her breath was terrible and our veterinarian wanted to perform a cleaning under anesthesia. She will be 14 in April, so, we decided to research alternatives … Great product and much better kisses…
Picky eater
★★★★☆· Feb 17, 2026
Elizabeth J.Verified buyer
So easy to use! My dog is a very picky eater and she actually seems to like her food more with this powder sprinkled on top! She is 14, has NEVER had her teeth cleaned, and they are beginning to look so much better after just a couple of months of use. Very pleased with the product so far!!
Tried chews
★★★★★· Mar 26, 2026
Erin K.Verified buyer
This has really worked for my dog! He had so much tartar that his dental sticks didn’t help and he refused to let me brush his teeth. This powder has significantly reduced his tartar and his teeth are looking great!
Skipped the cleaning
★★★★★· Dec 9, 2025
Jennie M.Verified buyer
Great checkup for my dog. Vet wanted to know what I had been doing. Very pleased and no cleaning needed.
When you'll see it
★★★★★· Oct 11, 2025
Susan N.Verified buyer
… I saw changes to most of his teeth in the first few weeks but his left upper molars were covered with brown tartar that didn't seem to be responding. After about six weeks the tartar seemed to be lighter and then one morning it was possible to see both of his molars. …
Easy routine
★★★★★· Apr 23, 2026
Deborah M.Verified buyer
Both of my girls like the flavor, so it’s easy to administer. I just sprinkle it on their food. I’ve noticed an improvement in their breath and that makes this a win win!
Inside the scoop

One Scoop Is 1,000 mg.Here’s Where Every Milligram Goes.

Nine human-grade ingredients: the studied active, the food that gets it eaten, and nothing hidden in between.

DE-01™ Dental Dogbiotic

Nine Ingredients. Every One Has a Job.

Makes
1 scoop
Weighs
1,000 mg
Prep
10 seconds
The DE-01 jar and a scoop of powder on a kitchen counter

100% Human-Grade

Nothing goes in your dog's bowl that isn't fit for your own plate. The studied active included.

Ingredients per 1 scoop

The Active

A level scoop of DE-01 powder

150 mg

Canine Oral Health Postbiotic (COHP)

A postbiotic made for a dog’s mouth, and published in three peer-reviewed studies in dogs.

  • Fresher breath by day 14, at this exact dose.*
  • 98% of the film that builds plaque broken up, in lab studies.**
  • Targets bad-breath bacteria and spares the good ones.***

Why Dogs Eat It

Bone broth powder on a spoon beside a mug of broth

283 mg Beef Bone Broth Powder

The biggest ingredient in the scoop, and the reason it goes on dinner like gravy.

A small pumpkin with a spoonful of pumpkin powder

248 mg Organic Pumpkin Powder

Certified organic pumpkin for a mild, familiar taste and a little natural fiber.

Thin slices of freeze-dried beef liver

37 mg Beef Liver Powder

A small amount of real liver, the smell that gets a picky dog’s nose in the bowl.

The Supporting Cast

Dried kelp fronds

150 mg Organic Kelp (Ascophyllum nodosum)

Certified organic seaweed, a natural source of iodine and trace minerals.

A small dish of green chlorella powder

50 mg Chlorella

Freshwater green algae, rich in chlorophyll, the pigment that makes plants green.

A tiny measuring spoon holding a few grains of white powder

2 mg Zinc Citrate

A mineral used in many toothpastes and dental products, here in a small, measured amount.

A single small sprig of flat-leaf parsley

5 mg Organic Parsley Powder

A pinch of organic parsley, the old breath herb. We won’t pretend 5 mg does the heavy lifting.

The Carrier

Oat flour on a spoon beside rolled oats

75 mg Oat Flour (Gluten Free)

Provides natural prebiotic fiber, which helps nourish beneficial bacteria in the gut. Since our formula works in part by supporting the oral–gut microbiome connection, that gentle prebiotic boost can help reinforce both oral and digestive health

Method

  1. Mix into your dog's food at mealtime. No brushing, no fighting.
  2. Repeat every day. Fresher breath by week 2, visible change by weeks 4 to 6.

Daily Serving Size

  • Tiny under 6 lbs1/2 Scoop
  • Small 6-25 lbs1 Scoop
  • Medium 25-75 lbs2 Scoops
  • Large 75+ lbs3 Scoops

Not in the scoop: No corn · No soy · No sugar · No gluten · No hormones · No antibiotics · No artificial flavors · No preservatives

Human-grade · Non-GMO · Lab tested · Made in USA using US & globally sourced ingredients

The DE-01 Dental Dogbiotic jar
60 DAYS
If it doesn't work

The Chews Kept Your Money. This Jar Has To Earn It.

The 3X Promise

Fresher Breath. Stronger Gums. Less Plaque.

60 days to find out.

Or every cent back. No questions.

Under 1 in 50 asked for their money back and got it. The rest kept the jar.

What waiting costs

Every Night You Wait, The Anesthesia Form Signs Itself.

An old grey-muzzled dog looks straight at the camera beside an unsigned anesthesia consent form, an empty steel bowl and a scoop.

“I’d rather have a dog with some dental issues than a dead dog”

A dog owner

Breath gets worse on its own.

+24%Day 7
+38%Day 14

The study at our 150mg dose: bad-breath compounds in the dogs that went without it.*

Where it ends: that estimate

$829.25 to $1,456.12

For one vet visit, tax included.

Or it starts tonight, with dinner: one scoop, before the film rebuilds. By day 14, you’ll smell the difference. The dog leans in, and this time you don’t lean away.

★★★★★· Sep 18, 2025
Jeannie K.Verified buyer
Bad breath is gone. … The older dog is 10 years old and has significant improvement in the area of her teeth and gums which the Vet wanted to operate on. I am thrilled that we are seeing great improvement. We are avoiding major surgery and suffering! So happy!
I'm Done Waiting

60 days. Or every cent back. No questions.

A woman laughs on her kitchen floor while her old beagle licks her chin
Pick your jar

Get Your Kisses Back. Then Keep Them Coming.

★★★★★4.8/51,922 Reviews
What arrives
  • Jars sized to your dog's weight
  • The scoop, for measured servings
  • Free shipping on orders $60+
  • The 3X Promise, 60-day money back
Step 1. Pick Your Dog's Weight
* Multiple dogs? Go up one weight class per dog.
Step 2. Choose Your Supply
  • Days 7-14, the breath starts to soften
  • Weeks 4-6, the brown starts to lift
  • Day 90, you stop checking.
Order now and ships by soon
60-Day GuaranteeFree Shipping $60+Human Grade Ingredients

The 3X Promise. Fresher Breath. Stronger Gums. Less Plaque.
60 days to try it. Or every cent back. No questions.

★★★★★4.8 out of 5Based on 1,922 Reviews

“Carly will be 14 in April and Izzy is 10. They are doing wonderfully on Dogbiotics! I can kiss them again and I do a lot more now that their breath is so much fresher. Their teeth look better too!!! Thank you Dogbiotics I will be a customer for life!!!”

Connie W., verified buyer

See more reviews ›

See Real Reviews

From Real Dog Moms
Real customer
Real customer
Real customer
Real customer
Real customer
In their words

That’s Our Case. Owners Get The Last Word.

Your questions

Frequently asked questions

Everything you want to know before you commit.

How It Works

DE-01 contains COHP, a clinically studied postbiotic that targets the source of bad breath inside your dog's oral microbiome: the bacteria that make the smell. It doesn't cover the odor up. The published study at our exact 150mg dose measured fresher breath by day 14. The label says you may see results in the first week, and daily use is what keeps them coming.

Yes. In lab studies, the postbiotic in DE-01 broke up 98% of the film that plaque builds on. It won't dissolve heavy tartar overnight. With daily use, owners typically see visible change around weeks 4 to 6. No published study runs that long yet, so that part is what owners report, not a measurement.

Dental chews work by scraping. The chewing rubs the tooth surface, mostly the outer face, and only while the chew lasts. They don't reach below the gumline, between the teeth, or into the oral microbiome. DE-01's postbiotic works biologically. It goes after the bacteria behind plaque, tartar and bad breath at the source, and it rides in on your dog's regular meal.

That's what it's built for. The film that plaque builds on rebuilds every night, so DE-01 goes in every day, like brushing, and the benefit adds up over time. It supports healthy teeth and gums from inside the oral microbiome, one dinner at a time.

Using DE-01

Only if you choose it. One-time purchase ships once, with no subscription and no commitment. Subscribe & Save takes money off every order and ships on schedule, and you can pause, skip, cancel or change the frequency anytime. Either way, the 60-day guarantee covers your order.

Once a day, mixed into your dog's regular food. That's it. 10 seconds, same meal every day.

Breath changes first. The label says you may see results in the first week, and the published study at our dose measured fresher breath by day 14. Visible change on the teeth typically shows around weeks 4 to 6 of daily use, and owners tell us day 90 is where it all adds up. Every published study stops at day 14, so the later milestones come from what owners report.

Almost universally, yes. The formula is made with beef bone broth and beef liver, so most dogs eat it right up. Even picky eaters tend to have no issues with this one.

Every day, for as long as you want the results. The benefit comes from consistency. The film rebuilds every night, so daily use keeps your dog's mouth where you want it. Stop, and the film builds back.

It goes by weight: ½ scoop under 6 lbs, 1 scoop for 6 to 25 lbs, 2 scoops for 25 to 75 lbs, and 3 scoops over 75 lbs. Once a day, on food. Every jar is sized to your dog's weight class, which is why Step 1 in the offer asks for it.

Absolutely. Sprinkle the scoop over whatever your dog eats: kibble, wet food, raw, homemade, or stirred into bone broth. The key is that your dog eats it with the meal.

Safety & Ingredients

Nine human-grade ingredients, every milligram printed on the jar and in the recipe card above. The active is COHP (Canine Oral Health Postbiotic), 150mg in every scoop, the ingredient behind all three published studies. Beef bone broth, organic pumpkin and beef liver are there so dogs eat it. Organic kelp, chlorella, organic parsley and zinc citrate round it out, with gluten-free oat flour as the carrier. No artificial additives, no fillers, no synthetic preservatives.

No. Sodium hexametaphosphate is a synthetic chelating agent found in many commercial dental foods and treats. We don't use it. DE-01 contains no synthetic chemicals, no artificial preservatives and no fillers. Human-grade ingredients only.

From 12 weeks old. The label says DE-01 is for dogs over 12 weeks. It isn't for dogs with thyroid issues, and it hasn't been proven safe for pregnant or nursing dogs. If you see any side effects, stop and call your vet.

DE-01 is formulated specifically for dogs. We don't recommend it for cats. The dosing and formulation are dog-specific, and some ingredients may not suit cats.

Made in USA using US & globally sourced ingredients, in an FDA-registered facility. We ship from our US fulfillment center, and most orders arrive within 3 to 5 business days.

Bring My Dog Close

60 days. Or every cent back. No questions.

The three published studies. Read them yourself:

Sordillo A, Casella L, Turcotte R, Sheth RU. A novel postbiotic reduces canine halitosis. Animals (Basel), 2025, 15(11), 1596. https://doi.org/10.3390/ani15111596

Sordillo A, Heldrich J, Turcotte R, Sheth RU. A postbiotic positively shifts the canine oral microbiome. J Vet Dent. 2026 OnlineFirst Apr 15. https://doi.org/10.1177/08987564261439741

Sordillo A, Turcotte R, Sheth RU. Canine halitosis improved with a postbiotic: a validation study. J Vet Dent. 2026 OnlineFirst May 7. https://doi.org/10.1177/08987564261437296

Don’t Spend The Last Years Turning Your Face Away. *Published clinical study at our 150mg dose, bad-breath compounds compared with dogs not given the active, day 14. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Breath, Or Anesthesia: 1 In 75 Sick Dogs Are Lost. *1 in 75: anesthesia- and sedation-related deaths in sick dogs (ASA 3 to 5). Brodbelt DC et al., Vet Anaesth Analg, 2008, 35(5), 365-73.

Measured, Not Promised. *98% and 41%: in lab studies. 9X: published clinical study, 250mg, day 7. +38%: published clinical study at our 150mg dose, day 14. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What You'll Notice, and When. *Published clinical study, 250mg, day 7. **Published clinical study at our 150mg dose, day 14. ***Weeks 4 to 6 and day 90: expected timeline based on customer experience, not a measured study endpoint. Individual results vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Here's Where Everything Else Stops. *On the active in DE-01 (Canine Oral Health Postbiotic), published 2025 to 2026 in Animals and the Journal of Veterinary Dentistry. Compared by category, not brand. Products within a category vary. **Day 14: published clinical study at our 150mg dose. ***Day 90: expected timeline based on customer experience, not a measured study endpoint. All three published studies measured through day 14. Individual results vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Reviews on this page. Real reviews from verified buyers, from the review widget on this page, quoted as written. Cuts are marked with an ellipsis (…). Individual results vary.

One Scoop Is 1,000 mg. Here’s Where Every Milligram Goes. *Published clinical study at our 150mg dose, day 14. **In lab studies. ***Published clinical study, 250mg, day 7. Amounts per 1 g scoop. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Chews Kept Your Money. This Jar Has To Earn It. Any DE-01 order, 60 days from the day you order. Email us and get the whole order total back, shipping included. You keep the jar. 1 in 50: DE-01 customers who ordered Feb 2025 to Jul 2026, refunds and chargebacks counted.

Every Night You Wait, The Anesthesia Form Signs Itself. *Published clinical study at our 150mg dose: the rise in bad-breath compounds in the 12 dogs given a placebo instead of the active, at day 7 and day 14. The estimate: one real 2024 estimate from a US veterinary clinic, showing a low and a high scenario, totals including tax. Individual results vary. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Up to 73% Off60 days to try it
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$299.00$79.97
Pick Your Dog's Weight
DE-01™ Dental Dogbiotic, Up to 73% Off60 days. Or every cent back. No questions.Medium Dog · 3 Months Supply · Subscribe & Save
$299.00$79.97
Pick Your Dog's WeightPick Your Dog's Weight